A yellow warning is in place from noon on Saturday until 9am on Monday and covers all regions of England other than the South West, the majority of Wales and parts of southern Scotland.
About 5cm of snow is expected widely across the Midlands, Wales and northern England, with as much as 20-30cm over high ground in Wales and/or the Pennines, the forecaster added.
Met Office meteorologist Tom Morgan said: "At the moment we've issued a very large snow warning for Saturday until Monday but it doesn't mean that everywhere within that warning could see snow, it's just a heads-up there could be some impacts.
"It's definitely going to start off as snow in many places but it's a question of how quickly that snow melts and turns back to rain, it's more likely that the snow won't last that long in southern England. "It's quite likely the warning wil...